Albendazole, 10% oral powder

Pharmacological properties

Albendazole is an anthelmintic from the benzimidazole group with a broad spectrum of activity. Albendazole affects the energy metabolism of helminths. It inhibits fumarate reductase synthesis, leading to a reduction in glycogen levels, which results in parasite death due to exhaustion.

Albendazole-L 10% is a broad-spectrum drug intended for the treatment of animals with parasitic diseases caused by gastrointestinal and pulmonary nematodes (roundworms), cestodes (tapeworms), and trematodes (flukes).

The bioavailability of Albendazole-L 10% is low. The time to reach maximum concentration of albendazole sulfoxide is 2–5 hours. It binds to plasma proteins at 70%.

The drug is excreted via bile through the intestines as the active metabolite albendazole sulfoxide, with only a small amount excreted in urine.

Method of administration and doses
Administer orally mixed with feed, as a single dose:

Cattle:

– nematodes, cestodes: 7.5 g per 100 kg of body weight;

– trematodes: 10.0 g per 100 kg of body weight.

Sheep, goats:

– nematodes, cestodes: 5.0 g per 100 kg of body weight;

– trematodes: 10.0 g per 100 kg of body weight.

Pigs:

– nematodes: 10.0 g per 100 kg of body weight.

Horses:

– nematodes: 8.0 g per 100 kg of body weight.

Poultry:

– nematodes, cestodes, trematodes: 8.0 g per 100 kg of body weight.