Angelmex, chewable tablets 400 mg №3

Pharmacological Properties

Albendazole is an anti-protozoal and anti-helminthic drug from the benzimidazole carbamate group. The drug acts on both intestinal and tissue parasites in the form of eggs, larvae, and adult helminths. The anti-helminthic action of albendazole is due to the inhibition of tubulin polymerization, leading to metabolic disruption and death of helminths.

Albendazole exhibits activity against intestinal parasites: nematodes – Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Cutaneus Larva Migrans; cestodes– Hymenolepsis nana, Taenia solium, Taenia saginata; trematodes– Opisthorchis viverrini, Clonorchis sinensis; protozoa– Giardia lamblia (intestinalis or duodenalis).

Albendazole also shows activity against tissue parasites, including cystic and alveolar echinococcosis caused by Echinococcus granulosus and Echinococcus multilocularis, respectively. The drug is effective in treating neurocysticercosis caused by Taenia solium larval infestations, capillariasis caused by Capillaria philippinensis, and gnathostomiasis caused by Gnathostoma spinigerum infestations.

Albendazole eliminates cysts or significantly reduces their size (up to 80%) in patients with granular echinococcosis. After treatment with albendazole, the number of non-viable cysts increases to 90%, compared to 10% in untreated patients. For cysts caused by Echinococcus multilocularis, full recovery is observed in a smaller proportion of patients, while most show improvement or stabilization.

Dosage and Administration

Intestinal Infections and Cutaneous Larva Migrans Syndrome
The drug should be taken with food. The tablet should be chewed or crushed and swallowed with a small amount of water. It is preferable to take the drug at the same time of day. If there is no improvement after three weeks, a second course of treatment should be administered.

Enterobiasis, Ancylostomiasis, Necatoriasis, Ascariasis, Trichuriasis
Adults and children over 3 years of age: 400 mg once daily (1 tablet) as a single dose.
For the treatment of enterobiasis, simultaneous treatment of all household members is recommended.
Strongyloidiasis (diagnosed or suspected), Taeniasis, Hymenolepiasis
Adults and children over 3 years of age: 400 mg once daily (1 tablet) for 3 days.In case of hymenolepiasis, a repeat course is recommended between days 10 and 21.
Clonorchiasis, Opisthorchiasis
Adults and children over 3 years of age: 400 mg (1 tablet) twice daily for 3 days.
Cutaneous Larva Migrans Syndrome
Adults and children over 3 years of age: 400 mg once daily for 1-3 days.
Giardiasis
Only children aged 3 to 12 years: 400 mg (1 tablet) once daily for 5 days.

Systemic Helminthic Infections (Long-term Treatment with High Doses)
The drug should be taken with food. The tablet should be chewed or crushed and swallowed with a small amount of water.
Children under 6 years: high-dose therapy is not recommended. For patients weighing less than 60 kg: 15 mg/kg/day, divided into 2 doses. For patients weighing more than 60 kg: 400 mg (1 tablet) twice daily. Maximum daily dose: 800 mg (2 tablets).

Cystic Echinococcosis: 28-day cycles. A 28-day cycle can be repeated up to 3 times after a 14-day break.

Children:
This formulation is not recommended for children under 3 years of age.