Opticef Suspension, Granules for Oral Use, 60 ml (32 g) – Agrofarm

Pharmacological Properties

Opticef Suspension from TOV “Agrofarm” contains Cefixime – a third-generation cephalosporin antibiotic for internal use. In vitro, it exhibits significant bactericidal activity against a wide range of gram-positive and gram-negative microorganisms.
Clinically effective in the treatment of infections caused by the most common pathogenic microorganisms, including Streptococcus pneumoniae, Streptococcus pyogenes, E. coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (both beta-lactamase-positive and -negative), Branhamella catarrhalis (both beta-lactamase-positive and -negative), and Enterobacter species. Cefixime has a high degree of stability in the presence of beta-lactamases.
Most strains of enterococci (Streptococcus faecalis, Streptococci group D) and Staphylococci (including coagulase-positive, coagulase-negative, and methicillin-resistant strains) are resistant to cefixime. Additionally, most strains of Pseudomonas, Bacteroides fragilis, Listeria monocytogenes, and Clostridia are resistant to cefixime.
Dosage and Administration for Opticef Suspension
Food intake does not affect the absorption of cefixime. The usual treatment course is 7 days, with the possibility of extending up to 14 days if necessary. For uncomplicated cystitis, the treatment course is 3 days.
Children aged 6 months to 10 years (weighing up to 50 kg): the recommended dose is 8 mg/kg daily, either as a single dose or 4 mg/kg every 12 hours, depending on the severity of the condition.
Adults and children aged 10 years and older (or weighing over 50 kg): the recommended dose is 400 mg daily as a single dose or 200 mg every 12 hours, depending on the severity of the condition.
Elderly patients: the medication should be prescribed at the recommended adult dose. Renal function should be monitored, and the dose should be adjusted in case of severe renal impairment (see “Renal Impairment”).
Renal Impairment: Cefixime can be used in cases of impaired renal function. For patients with a creatinine clearance of 20 ml/min or higher, a standard dose and regimen should be prescribed. For patients with a creatinine clearance below 20 ml/min, the daily dose should be reduced by 50%. This also applies to patients undergoing continuous ambulatory peritoneal dialysis or hemodialysis.
Preparation of the Suspension.
For internal use only.
For 60 mL of suspension (100 mg/5 mL): shake the bottle several times before reconstitution, add 40 mL of cooled boiled water at room temperature in two portions, and shake well to obtain a homogeneous suspension.
For 100 mL of suspension (100 mg/5 mL): shake the bottle several times before reconstitution, add 66 mL of cooled boiled water at room temperature in two portions, and shake well to obtain a homogeneous suspension.
Shake the prepared suspension thoroughly before each use. The suspension should be measured with the provided measuring spoon.

Children
The medication is recommended for children aged 6 months and older. The safety and efficacy of cefixime in children younger than 6 months have not been established, so its use in this age group is not recommended.